Genetically Engineered Animal Models

 

 

Commonly used transgenic and knockout mouse model

Autoimmune Defects

 Mouse Model

J001058

NZW/LacJ

Systemic Lupus Erythematosus(SLE)

J000486

MRL/MpJ

Systemic Lupus Erythematosus(SLE)

J001021

B6Smn.C3-Tnfsf6gld/J

Systemic Lupus Erythematosus(SLE), Lymphadenopathy, Systemic Autoimmune Diseases

J000482

B6.MRL-Faslpr/J

Systemic Lupus Erythematosus (SLE)

Metabolic Diseases

J003548

C57BL/6-Ins2Akita/J

Diabetes

J001976

NOD/LtJ

Diabetes

J000632

C57BL/6J-Lepob/J

Diabetes

J000697

B6.Cg-m +/+Leprdb/J

Diabetes

J000642

BKS.Cg-m +/+ Leprdb/J

Diabetes (The best model)

High Blood Pressure, High Cholesterol, Atherosclerosis

J002684

B6.129P2-Nos3tm1Unc/J

Hypertension

J002207

B6.129S7-Ldlrtm1Her/J

Atherosclerosis

J002052

B6.129P2-Apoetm1Unc/J

Atherosclerosis

J003904

B6.CBA-Tg(CETP)5203Tall/J

Cholesterol Metabolism

Alzheimer's Disease, Parkinson's Disease

J004462

B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J

Double transgenic Alzheimer’s Disease (AD)

DOO33

B6;SJL-Tg(APPSWE)2576Kha

Alzheimer's Disease (AD) model

J004479

B6;C3H-Tg(SNCA)83Vle/J

Parkinson's Disease (PD) model

J008169

B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J

Neurodegenerative Diseases, Alzheimer’s Disease (AD)

J006554

B6SJL-Tg(APPSwFlLon,PSEN1*M146L*

L286V)6799Vas/J

Neurodegenerative Diseases,, Alzheimer’s disease (AD)

Tumor

J002020

C57BL/6J-ApcMin/J

Intestinal Tumour

J002101

B6.129S2-Trp53tm1Tyj/J

Lymphoma, Osteosarcoma

J006440

B6.129S4-Ptentm1Hwu/J

Tumor suppressor genes

J003081

STOCK Ptch1tm1Mps/J

Brain Tumor

Cre

J003314

FVB/N-Tg(EIIa-cre)C5379Lmgd

Tissue broad-spectrum expression

D0034

CMV-Cre

Systemic Expression

D0082

SM22-cre

Specific express in cardiac cells and smooth muscle cells

D0061

Teto-Cre

Inducible to express, Tet expression system

J003556

B6.Cg-Tg(Mx1-cre)1Cgn

Interferon-induced expression

Others

D0102

FVB -Tg(SFTPC-rtTA)5Jaw

Specific express the lung epithelial rtTA, Tet-on expression system

J003946

129S4/SvJaeSor-Gt(ROSA)26Sortm1

(FLP1)Dym/J

High expression of FLPe recombinase

J004077

B6;129-Gt(ROSA)26Sortm2Sho/J

The loxP mouse containing GFP, it can be used to verify the expression of Cre

J002356

C57BL/6J-Tg(pPGKneobpA)3Ems

The transgenic mouse containing neomycin resistance gene

       

Note: (1) We got the first production license of genetic engineering experimental animals in

Guangdong province.

(2)The red colour marked strains can be large-scale provided, the others need to custom-made.

For the custom-made animal model

What can we do?

(1)   We can provide the complete set service, from gene sequences to positive mice.

(2)   We can design and build targeting vector, target and select the embryonic stem cells (ES cells),

microinjection.

(3)   We can detect the heritability in offspring animals, preliminary phenotypic analyses.

(4)   We can provide 5-10 positive transgenic animalsThe Founderswithin 9 months.

(5)   We can provide 4 or more F1 heterozygous gene knockout mice within 15 months.